<i>SCN5A</i> Variants as Genetic Arrhythmias Triggers for Familial Bileaflet Mitral Valve Prolapse

<i>SCN5A</i> Variants as Genetic Arrhythmias Triggers for Familial Bileaflet Mitral Valve Prolapse

Mitral valve prolapse (MVP) is a common valvular heart defect with variable outcomes. Several studies reported MVP as an underestimated cause of life-threatening arrhythmias and sudden cardiac death (SCD), mostly in young adult women. Herein, we report a clinical and genetic investigation of a famil...

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Bibliographic Details
Main Authors: Hager Jaouadi, Alexis Théron, Jérôme Hourdain, Hélène Martel, Karine Nguyen, Raja Habachi, Jean-Claude Deharo, Frédéric Collart, Jean-François Avierinos, Stéphane Zaffran
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
familial mitral valve prolapse
genetic arrhythmia substrate
<i>SCN5A</i> mutation
H558R polymorphism
syncope
resuscitated sudden cardiac death
Online Access:https://www.mdpi.com/1422-0067/23/22/14447

Internet

https://www.mdpi.com/1422-0067/23/22/14447

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