A high degree of LINE-1 hypomethylation is a unique feature of early-onset colorectal cancer.

A high degree of LINE-1 hypomethylation is a unique feature of early-onset colorectal cancer.

Early-onset colorectal cancer (CRC) represents a clinically distinct form of CRC that is often associated with a poor prognosis. Methylation levels of genomic repeats such as LINE-1 elements have been recognized as independent factors for increased cancer-related mortality. The methylation status of...

Full description

Bibliographic Details
Main Authors: Marina Antelo, Francesc Balaguer, Jinru Shia, Yan Shen, Keun Hur, Leticia Moreira, Miriam Cuatrecasas, Luis Bujanda, Maria Dolores Giraldez, Masanobu Takahashi, Ana Cabanne, Mario Edmundo Barugel, Mildred Arnold, Enrique Luis Roca, Montserrat Andreu, Sergi Castellvi-Bel, Xavier Llor, Rodrigo Jover, Antoni Castells, C Richard Boland, Ajay Goel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3458035?pdf=render

Internet

http://europepmc.org/articles/PMC3458035?pdf=render

Similar Items