nanoRAPIDS as an analytical pipeline for the discovery of novel bioactive metabolites in complex culture extracts at the nanoscale

Abstract Microbial natural products form the basis of most of the antibiotics used in the clinic. The vast majority has not yet been discovered, among others because the hidden chemical space is obscured by previously identified (and typically abundant) antibiotics in culture extracts. Efficient der...

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Detalles Bibliográficos
Autores principales: Isabel Nuñez Santiago, Nataliia V. Machushynets, Marija Mladic, Doris A. van Bergeijk, Somayah S. Elsayed, Thomas Hankemeier, Gilles P. van Wezel
Formato: Artículo
Lenguaje:English
Publicado: Nature Portfolio 2024-04-01
Colección:Communications Chemistry
Acceso en línea:https://doi.org/10.1038/s42004-024-01153-y