Fluorescence microscopy-based sensitive method to quantify dopaminergic neurodegeneration in a Drosophila model of Parkinson’s disease

Fluorescence microscopy-based sensitive method to quantify dopaminergic neurodegeneration in a Drosophila model of Parkinson’s disease

Death of dopaminergic (DAergic) neurons in the substantia nigra pars compacta of the human brain is the characteristic pathological feature of Parkinson’s disease (PD). On exposure to neurotoxicants, Drosophila too exhibits mobility defects and diminished levels of brain dopamine. In the fly model o...

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Bibliographic Details
Main Authors: Mohamad Ayajuddin, Rahul Chaurasia, Abhik Das, Priyanka Modi, Limamanen Phom, Zevelou Koza, Sarat Chandra Yenisetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Neuroscience
Subjects:
dopamine
neurodegeneration
fluorescence intensity
tyrosine hydroxylase
Drosophila
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1158858/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2023.1158858/full

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