Evaluation of thiadiazine-based PET radioligands for imaging the AMPA receptor

Evaluation of thiadiazine-based PET radioligands for imaging the AMPA receptor

As a subclass of ionotropic glutamate receptors (iGluRs), α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors have been implicated in various neurological disorders and neurodegenerative diseases. To further our understanding of AMPA receptor-related disorders in the central nervo...

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Bibliographic Details
Main Authors: Jiahui Chen, Wenqing Ran, Yiman Huang, Junjie Wei, Jian Rong, Huiyi Wei, Yinlong Li, Guocong Li, Zhen Chen, Lee Collier, Nehal H. Elghazawy, Wolfgang Sippl, Ahmed Haider, Kai Liao, Chenchen Dong, Ying Li, Hao Xu, Wenpeng He, Lu Wang, Steven H. Liang
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
AMPA receptors
Central nervous system (CNS)
Positron emission tomography
Positive allosteric modulator (PAM)
Fluorine 18 (18F)
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223016402

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http://www.sciencedirect.com/science/article/pii/S0753332223016402

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