Performance of Pyridylthiourea‐Polyethylenimine Polyplex for siRNA‐Mediated Liver Cancer Therapy in Cell Monolayer, Spheroid, and Tumor Xenograft Models

Performance of Pyridylthiourea‐Polyethylenimine Polyplex for siRNA‐Mediated Liver Cancer Therapy in Cell Monolayer, Spheroid, and Tumor Xenograft Models

Medical application of siRNAs relies on methods for delivering nucleic acids into the cytosol. Synthetic carriers, which assemble with nucleic acids into delivery systems, show promises for cancer therapy but efficiency remains to be improved. In here, the effectiveness of pyridylthiourea‐polyethyle...

Full description

Bibliographic Details
Main Authors: Jean Baptiste Gossart, Etienne Pascal, Florent Meyer, Emilie Heuillard, Mathieu Gonçalves, Francine Gossé, Eric Robinet, Benoît Frisch, Cendrine Seguin, Guy Zuber
Format: Article
Language:English
Published: Wiley 2017-07-01
Series:Global Challenges
Subjects:
delivery system
liver cancer
polo‐like kinase
polyethylenimine
siRNA
Online Access:https://doi.org/10.1002/gch2.201700013

Internet

https://doi.org/10.1002/gch2.201700013

Similar Items