Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the <i>Plasmodium</i> Life Cycle

Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the <i>Plasmodium</i> Life Cycle

A recently developed artemisinin-quinoline hybrid, named 163A, has been shown to display potent activity against the asexual blood stage of <i>Plasmodium</i>, the malaria parasite. In this study, we determined its in vitro cytotoxicity to mammalian cells, its potency to suppress <i>...

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Bibliographic Details
Main Authors: Helenita C. Quadros, Aysun Çapcı, Lars Herrmann, Sarah D’Alessandro, Diana Fontinha, Raquel Azevedo, Wilmer Villarreal, Nicoletta Basilico, Miguel Prudêncio, Svetlana B. Tsogoeva, Diogo R. M. Moreira
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Pharmaceuticals
Subjects:
malaria
<i>Plasmodium</i>
hemozoin
heterobivalent
artemisinin
hybrids
Online Access:https://www.mdpi.com/1424-8247/14/11/1129

Internet

https://www.mdpi.com/1424-8247/14/11/1129

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