c-Abl Deficiency Provides Synaptic Resiliency Against Aβ-Oligomers

c-Abl Deficiency Provides Synaptic Resiliency Against Aβ-Oligomers

Spine pathology has been implicated in the early onset of Alzheimer’s disease (AD), where Aβ-Oligomers (AβOs) cause synaptic dysfunction and loss. Previously, we described that pharmacological inhibition of c-Abl prevents AβOs-induced synaptic alterations. Hence, this kinase seems to be a key elemen...

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Bibliographic Details
Main Authors: Daniela A. Gutierrez, Lina M. Vargas, América Chandia-Cristi, Catalina de la Fuente, Nancy Leal, Alejandra R. Alvarez
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer’s disease
c-Abl tyrosine kinase
synapse
Aβ-oligomers
dendritic spines
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00526/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00526/full

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