Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin

Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin

Abstract Wilms tumor (WT) is the most common renal malignancy of childhood. Despite improvements in the overall survival, relapse occurs in ~15% of patients with favorable histology WT (FHWT). Half of these patients will succumb to their disease. Identifying novel targeted therapies remains challeng...

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Bibliographic Details
Main Authors: Karuna Mittal, Garrett W. Cooper, Benjamin P. Lee, Yongdong Su, Katie T. Skinner, Jenny Shim, Hunter C. Jonus, Won Jun Kim, Mihir Doshi, Diego Almanza, Bryan D. Kynnap, Amanda L. Christie, Xiaoping Yang, Glenn S. Cowley, Brittaney A. Leeper, Christopher L. Morton, Bhakti Dwivedi, Taylor Lawrence, Manali Rupji, Paula Keskula, Stephanie Meyer, Catherine M. Clinton, Manoj Bhasin, Brian D. Crompton, Yuen-Yi Tseng, Jesse S. Boehm, Keith L. Ligon, David E. Root, Andrew J. Murphy, David M. Weinstock, Prafulla C. Gokhale, Jennifer M. Spangle, Miguel N. Rivera, Elizabeth A. Mullen, Kimberly Stegmaier, Kelly C. Goldsmith, William C. Hahn, Andrew L. Hong
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06140-6

Internet

https://doi.org/10.1038/s42003-024-06140-6

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