Glutamine metabolism regulates endothelial to hematopoietic transition and hematopoietic lineage specification

Abstract During hematopoietic development, definitive hematopoietic cells are derived from hemogenic endothelial (HE) cells through a process known as endothelial to hematopoietic transition (EHT). During EHT, transitioning cells proliferate and undergo progressive changes in gene expression culmina...

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Bibliographic Details
Main Authors: Leal Oburoglu, Els Mansell, Niels-Bjarne Woods
Format: Article
Language:English
Published: Nature Portfolio 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97194-7