Endogenous Mouse Dicer Is an Exclusively Cytoplasmic Protein.

Dicer is a large multi-domain protein responsible for the ultimate step of microRNA and short-interfering RNA biogenesis. In human and mouse cell lines, Dicer has been shown to be important in the nuclear clearance of dsRNA as well as the establishment of chromatin modifications. Here we set out to...

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Detalles Bibliográficos
Autores principales: Christian Much, Tania Auchynnikava, Dinko Pavlinic, Andreas Buness, Juri Rappsilber, Vladimir Benes, Robin Allshire, Dónal O'Carroll
Formato: Artículo
Lenguaje:English
Publicado: Public Library of Science (PLoS) 2016-06-01
Colección:PLoS Genetics
Acceso en línea:https://doi.org/10.1371/journal.pgen.1006095