Methotrexate inhibits BMP4 and abrogates the hypertrophic chondrocyte phenotype of synovial fibroblasts in juvenile idiopathic arthritis

Methotrexate inhibits BMP4 and abrogates the hypertrophic chondrocyte phenotype of synovial fibroblasts in juvenile idiopathic arthritis

Abstract Background Juvenile Idiopathic Arthritis (JIA) induces growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis. FLS overexpress bone morphogenetic protein 4 (BMP4) and have a chondrocyte-like phenotype. FLS contribute directly to jo...

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Bibliographic Details
Main Authors: Megan M. Simonds, Samuel T. Freer, Anne Marie C. Brescia
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Pediatric Rheumatology Online Journal
Subjects:
Juvenile idiopathic arthritis
Methotrexate
Bone morphogenetic protein 4
Synoviocytes
Chondrocytes
Online Access:https://doi.org/10.1186/s12969-023-00940-6

Internet

https://doi.org/10.1186/s12969-023-00940-6

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