Genetic and Pharmacological Inhibition of Astrocytic Mysm1 Alleviates Depressive‐Like Disorders by Promoting ATP Production

Genetic and Pharmacological Inhibition of Astrocytic Mysm1 Alleviates Depressive‐Like Disorders by Promoting ATP Production

Abstract Major depressive disorder (MDD) is a leading cause of disability worldwide. A comprehensive understanding of the molecular mechanisms of this disorder is critical for the therapy of MDD. In this study, it is observed that deubiquitinase Mysm1 is induced in the brain tissues from patients wi...

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Bibliographic Details
Main Authors: Heyang Zhang, Shuirong Liu, Qiaozhen Qin, Zhenhua Xu, Yannv Qu, Yadi Wang, Jianing Wang, Zhangzhen Du, Shanshan Yuan, Shunming Hong, Zhilin Chang, Wenyan He, Xinlong Yan, Yiran Lang, Rongyu Tang, Yan Wang, Lingling Zhu, Xiaoxia Jiang
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Advanced Science
Subjects:
antidepressant effect
aspirin
astrocyte
ATP
Mysm1
Online Access:https://doi.org/10.1002/advs.202204463

Internet

https://doi.org/10.1002/advs.202204463

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