The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development

The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development

Abstract Glucose homeostasis is maintained by hormones secreted from different cell types of the pancreatic islets and controlled by manifold input including signals mediated through G protein-coupled receptors (GPCRs). RNA-seq analyses revealed expression of numerous GPCRs in mouse and human pancre...

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Main Authors: Juliane Röthe, Robert Kraft, Albert Ricken, Isabell Kaczmarek, Madlen Matz-Soja, Karsten Winter, André Nguyen Dietzsch, Julia Buchold, Marie-Gabrielle Ludwig, Ines Liebscher, Torsten Schöneberg, Doreen Thor
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-05783-9

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https://doi.org/10.1038/s42003-024-05783-9

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