RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

The decline of DNA and protein quality control contributes to organismal ageing. Here, Sonet al. report that nonsense-mediated mRNA decay, a RNA quality control mechanism, is enhanced in long-lived daf-2 mutant worms and contributes to their longevity by regulating expression of the yars-2/tyrosyl t...

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Bibliographic Details
Main Authors: Heehwa G. Son, Mihwa Seo, Seokjin Ham, Wooseon Hwang, Dongyeop Lee, Seon Woo A. An, Murat Artan, Keunhee Seo, Rachel Kaletsky, Rachel N. Arey, Youngjae Ryu, Chang Man Ha, Yoon Ki Kim, Coleen T. Murphy, Tae-Young Roh, Hong Gil Nam, Seung-Jae V. Lee
Format: Article
Language:English
Published: Nature Portfolio 2017-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14749

Internet

https://doi.org/10.1038/ncomms14749

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