One-step preservation of phosphoproteins and tissue morphology at room temperature for diagnostic and research specimens.

One-step preservation of phosphoproteins and tissue morphology at room temperature for diagnostic and research specimens.

There is an urgent need to measure phosphorylated cell signaling proteins in cancer tissue for the individualization of molecular targeted kinase inhibitor therapy. However, phosphoproteins fluctuate rapidly following tissue procurement. Snap-freezing preserves phosphoproteins, but is unavailable in...

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Bibliographic Details
Main Authors: Claudius Mueller, Kirsten H Edmiston, Calvin Carpenter, Eoin Gaffney, Ciara Ryan, Ronan Ward, Susan White, Lorenzo Memeo, Cristina Colarossi, Emanuel F Petricoin, Lance A Liotta, Virginia Espina
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3157466?pdf=render

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http://europepmc.org/articles/PMC3157466?pdf=render

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