Safety and efficacy of single dose versus multiple doses of AmBisome for treatment of visceral leishmaniasis in eastern Africa: a randomised trial.

Anti-leishmanial drug regimens that include a single dose AmBisome could be suitable for eastern African patients with symptomatic visceral leishmaniasis (VL) but the appropriate single dose is unknown.A multi-centre, open-label, non-inferiority, randomized controlled trial with an adaptive design,...

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Main Authors: Eltahir A G Khalil, Teklu Weldegebreal, Brima M Younis, Raymond Omollo, Ahmed M Musa, Workagegnehu Hailu, Abuzaid A Abuzaid, Thomas P C Dorlo, Zewdu Hurissa, Sisay Yifru, William Haleke, Peter G Smith, Sally Ellis, Manica Balasegaram, Ahmed M EL-Hassan, Gerard J Schoone, Monique Wasunna, Robert Kimutai, Tansy Edwards, Asrat Hailu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3894173?pdf=render