Maternal Obesity during Pregnancy Alters Daily Activity and Feeding Cycles, and Hypothalamic Clock Gene Expression in Adult Male Mouse Offspring

Maternal Obesity during Pregnancy Alters Daily Activity and Feeding Cycles, and Hypothalamic Clock Gene Expression in Adult Male Mouse Offspring

An obesogenic diet adversely affects the endogenous mammalian circadian clock, altering daily activity and metabolism, and resulting in obesity. We investigated whether an obese pregnancy can alter the molecular clock in the offspring hypothalamus, resulting in changes to their activity and feeding...

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Bibliographic Details
Main Authors: Jane K. Cleal, Kimberley D. Bruce, Jasmin L. Shearer, Hugh Thomas, Jack Plume, Louise Gregory, James N. Shepard, Kerry L. Spiers-Fitzgerald, Ravi Mani, Rohan M. Lewis, Karen A. Lillycrop, Mark A. Hanson, Christopher D. Byrne, Felino R. Cagampang
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
high fat diet
maternal obesity
pregnancy
circadian clocks
appetite
suprachiasmatic nucleus
arcuate nucleus
mouse
activity
Online Access:https://www.mdpi.com/1422-0067/20/21/5408

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https://www.mdpi.com/1422-0067/20/21/5408

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