Seq2Neo: A Comprehensive Pipeline for Cancer Neoantigen Immunogenicity Prediction

Seq2Neo: A Comprehensive Pipeline for Cancer Neoantigen Immunogenicity Prediction

Neoantigens derived from somatic DNA alterations are ideal cancer-specific targets. In recent years, the combination therapy of PD-1/PD-L1 blockers and neoantigen vaccines has shown clinical efficacy in original PD-1/PD-L1 blocker non-responders. However, not all somatic DNA mutations result in immu...

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Bibliographic Details
Main Authors: Kaixuan Diao, Jing Chen, Tao Wu, Xuan Wang, Guangshuai Wang, Xiaoqin Sun, Xiangyu Zhao, Chenxu Wu, Jinyu Wang, Huizi Yao, Casimiro Gerarduzzi, Xue-Song Liu
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
immunogenicity
immunotherapy
bioinformatics pipeline
deep learning
Online Access:https://www.mdpi.com/1422-0067/23/19/11624

Internet

https://www.mdpi.com/1422-0067/23/19/11624

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