Adsorption of Chiral [5]-Aza[5]helicenes on DNA Can Modify Its Hydrophilicity and Affect Its Chiral Architecture: A Molecular Dynamics Study

Adsorption of Chiral [5]-Aza[5]helicenes on DNA Can Modify Its Hydrophilicity and Affect Its Chiral Architecture: A Molecular Dynamics Study

Helicenes are interesting chiral molecules without asymmetric carbon atoms but with intrinsic chirality. Functionalized 5-Aza[5]helicenes can form non-covalent complexes with anticancer drugs and therefore be potential carriers. The paper highlights the different structural selectivity for DNA bindi...

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Bibliographic Details
Main Authors: Giuseppina Raffaini, Andrea Mele, Tullio Caronna
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Materials
Subjects:
chirality
intrinsic chirality
helicenes
structural selectivity
adsorption
DNA recognition
Online Access:https://www.mdpi.com/1996-1944/13/21/5031

Internet

https://www.mdpi.com/1996-1944/13/21/5031

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