Sequence-based prediction of the intrinsic solubility of peptides containing non-natural amino acids

Sequence-based prediction of the intrinsic solubility of peptides containing non-natural amino acids

Abstract Non-natural amino acids are increasingly used as building blocks in the development of peptide-based drugs as they expand the available chemical space to tailor function, half-life and other key properties. However, while the chemical space of modified amino acids (mAAs) such as residues co...

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Bibliographic Details
Main Authors: Marc Oeller, Ryan J. D. Kang, Hannah L. Bolt, Ana L. Gomes dos Santos, Annika Langborg Weinmann, Antonios Nikitidis, Pavol Zlatoidsky, Wu Su, Werngard Czechtizky, Leonardo De Maria, Pietro Sormanni, Michele Vendruscolo
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42940-w

Internet

https://doi.org/10.1038/s41467-023-42940-w

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