Modulation of COX-2 and NADPH oxidase-4 by alpha-lipoic acid ameliorates busulfan-induced pulmonary injury in rats

Modulation of COX-2 and NADPH oxidase-4 by alpha-lipoic acid ameliorates busulfan-induced pulmonary injury in rats

Aims: This study aimed to explore the potential protective effect of α-lipoic acid on busulfan-induced pulmonary fibrosis in rats. Main methods: Eighteen adult male rats were divided into 3 groups; control, busulfan, and busulfan plus α-lipoic acid groups. Lung index ratio, serum level of proinflamm...

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Bibliographic Details
Main Authors: Mona G. Elhadidy, Ahlam Elmasry, Hassan Reda Hassan Elsayed, Mohammad El-Nablaway, Shereen Hamed, Mahmoud M. Elalfy, Mohammed R. Rabei
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Heliyon
Subjects:
Busulfan
Pulmonary fibrosis
α-lipoic acid (ALA)
Apoptosis
COX-2
NOX-4
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402102274X

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http://www.sciencedirect.com/science/article/pii/S240584402102274X

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