Weight increase in people with cystic fibrosis on CFTR modulator therapy is mainly due to increase in fat mass

Weight increase in people with cystic fibrosis on CFTR modulator therapy is mainly due to increase in fat mass

Background: Ivacaftor, the first CFTR modulator drug, leads to significant long-term improvement in lung function and weight gain. The mechanism as well as the long-term impact of ivacaftor on weight, resting energy expenditure (REE) and body composition remains to be explored.Methods: This prospect...

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Bibliographic Details
Main Authors: Marialena Mouzaki, Annie Dupuis, Julie Avolio, Katherine Griffin, Felix Ratjen, Elizabeth Tullis, Tanja Gonska
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Pharmacology
Subjects:
cystic fibrosis
ivacaftor treatment
nutritional status
body composition
resting energy expenditure trail registration: NCT03390985 BMI-body mass index
CFTR modulator treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1157459/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1157459/full

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