In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids

In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids

Malaria is a parasitic tropical disease that kills around 600,000 patients every year. The emergence of resistant Plasmodium falciparum parasites to artemisinin-based combination therapies (ACTs) represents a significant public health threat, indicating the urgent need for new effective compounds to...

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Bibliographic Details
Main Authors: Birgit Viira, Thibault Gendron, Don Antoine Lanfranchi, Sandrine Cojean, Dragos Horvath, Gilles Marcou, Alexandre Varnek, Louis Maes, Uko Maran, Philippe M. Loiseau, Elisabeth Davioud-Charvet
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Molecules
Subjects:
antimalarial
quantitative structure-activity relationships (QSAR)
curcuminoid
Michael addition
Plasmodium falciparum
thioredoxin reductase
in silico
Online Access:http://www.mdpi.com/1420-3049/21/7/853

Internet

http://www.mdpi.com/1420-3049/21/7/853

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