Live Vaccines Have Different NK Cells and Neutrophils Requirements for the Development of a Protective Immune Response Against Tuberculosis

Live Vaccines Have Different NK Cells and Neutrophils Requirements for the Development of a Protective Immune Response Against Tuberculosis

It has been shown that neutrophils drive NK cells to activate DCs while NK cells regulate neutrophils survival. In response to mycobacteria, NK cells proliferate and produces IFN-γ, that appears to regulate the neutrophilic inflammatory responses to both M. tuberculosis infection and BCG vaccination...

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Bibliographic Details
Main Authors: Ana Paula Junqueira-Kipnis, Monalisa Martins Trentini, Lázaro Moreira Marques Neto, André Kipnis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
protection
TB vaccine
DC
NK depletion
neutrophil depletion
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00741/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00741/full

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