Hydrogen-Bonding Capacity and Brain Penetration
Brain penetration has been reported to correlate with ?log P, defined as log P (octan-1-ol/H2O) – log P (alkane/H2O). Another recent development, describing log P as the Sum of a cavity or volume contribution and H-bonding capability, the latter expressed by ?solvent values, prompted us to...
| Main Authors: | , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
1992-07-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/2150 |