Effect of tauroursodeoxycholic acid on survival and safety in amyotrophic lateral sclerosis: a retrospective population-based cohort studyResearch in context

Effect of tauroursodeoxycholic acid on survival and safety in amyotrophic lateral sclerosis: a retrospective population-based cohort studyResearch in context

Summary: Background: Oral tauroursodeoxycholic acid (TUDCA) is a commercial drug currently tested in patients with amyotrophic lateral sclerosis (ALS) both singly and combined with sodium phenylbutyrate. This retrospective study aimed to investigate, in a real-world setting, whether TUDCA had an im...

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Main Authors: Elisabetta Zucchi, Umberto Maria Musazzi, Guido Fedele, Ilaria Martinelli, Giulia Gianferrari, Cecilia Simonini, Nicola Fini, Andrea Ghezzi, Maria Caputo, Elisabetta Sette, Veria Vacchiano, Lucia Zinno, Pietro Anceschi, Elena Canali, Marco Vinceti, Salvatore Ferro, Jessica Mandrioli, Laura Ferri, Annalisa Gessani, Rocco Liguori, Pietro Cortelli, Roberto Michelucci, Fabrizio Salvi, Ilaria Bartolomei, Anna Maria Borghi, Andrea Zini, Rita Rinaldi, Valeria Tugnoli, Maura Pugliatti, Luca Codeluppi, Franco Valzania, Filippo Stragliati, Andi Nuredini, Sonia Romano, Alessandro D'Orsi, Liborio Parrino, Doriana Medici, Giovanna Pilurzi, Emilio Terlizzi, Donata Guidetti, Silvia De Pasqua, Mario Santangelo, Paola De Massis, Matteo Gizzi, Mario Casmiro, Pietro Querzani, Simonetta Morresi, Maria Vitiello, Marco Longoni, Alberto Patuelli, Susanna Malagù, Francesca Bianchi, Marco Currò Dossi, Cristiana Ganino
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:EClinicalMedicine
Subjects:
Amyotrophic lateral sclerosis
Tauroursodeoxycholic acid
Real-world evidence
Propensity score matching
Survival
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537023004339

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http://www.sciencedirect.com/science/article/pii/S2589537023004339

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