N-terminal arginines modulate plasma-membrane localization of Kv7.1/KCNE1 channel complexes.

N-terminal arginines modulate plasma-membrane localization of Kv7.1/KCNE1 channel complexes.

BACKGROUND AND OBJECTIVE: The slow delayed rectifier current (I(Ks)) is important for cardiac action potential termination. The underlying channel is composed of Kv7.1 α-subunits and KCNE1 β-subunits. While most evidence suggests a role of KCNE1 transmembrane domain and C-terminus for the interactio...

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Bibliographic Details
Main Authors: Zenawit Girmatsion, Peter Biliczki, Ina Takac, Christin Schwerthelm, Stefan H Hohnloser, Joachim R Ehrlich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3208574?pdf=render

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http://europepmc.org/articles/PMC3208574?pdf=render

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