A novel method to adjust efficacy estimates for uptake of other active treatments in long-term clinical trials.

A novel method to adjust efficacy estimates for uptake of other active treatments in long-term clinical trials.

<h4>Background</h4>When rates of uptake of other drugs differ between treatment arms in long-term trials, the true benefit or harm of the treatment may be underestimated. Methods to allow for such contamination have often been limited by failing to preserve the randomization comparisons....

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Bibliographic Details
Main Authors: John Simes, Merryn Voysey, Rachel O'Connell, Paul Glasziou, James D Best, Russell Scott, Christopher Pardy, Karen Byth, David R Sullivan, Christian Ehnholm, Anthony Keech, FIELD Study Investigators
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20072614/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20072614/pdf/?tool=EBI

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