Lighting Up the Fire in the Microenvironment of Cold Tumors: A Major Challenge to Improve Cancer Immunotherapy

Lighting Up the Fire in the Microenvironment of Cold Tumors: A Major Challenge to Improve Cancer Immunotherapy

Immunotherapy includes immune checkpoint inhibitors (ICI) such as antibodies targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) or the programmed cell death protein/programmed death ligand 1 (PD-1/PD-L1) axis. Experimental and clinical evidence show that immunotherapy based on immune che...

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Bibliographic Details
Main Authors: Alice Benoit, Guillaume Vogin, Caroline Duhem, Guy Berchem, Bassam Janji
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
immunotherapy
immune checkpoint inhibitors
tumor microenvironment
metabolic reprogramming
hypoxia
Online Access:https://www.mdpi.com/2073-4409/12/13/1787

Internet

https://www.mdpi.com/2073-4409/12/13/1787

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