USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP

USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP

C-terminal binding protein (CtBP) interacting protein (CtIP) is a fundamental factor for the initiation of DNA end resection to initiate DNA repair. Here the authors reveal mechanistic insights into the regulation of CtIP via the deubiquitinase USP52.

Bibliographic Details
Main Authors: Ming Gao, Guijie Guo, Jinzhou Huang, Jake A. Kloeber, Fei Zhao, Min Deng, Xinyi Tu, Wootae Kim, Qin Zhou, Chao Zhang, Ping Yin, Kuntian Luo, Zhenkun Lou
Format: Article
Language:English
Published: Nature Portfolio 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19202-0

Internet

https://doi.org/10.1038/s41467-020-19202-0

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