USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP
C-terminal binding protein (CtBP) interacting protein (CtIP) is a fundamental factor for the initiation of DNA end resection to initiate DNA repair. Here the authors reveal mechanistic insights into the regulation of CtIP via the deubiquitinase USP52.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19202-0 |
| _version_ | 1819044562393366528 |
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| author | Ming Gao Guijie Guo Jinzhou Huang Jake A. Kloeber Fei Zhao Min Deng Xinyi Tu Wootae Kim Qin Zhou Chao Zhang Ping Yin Kuntian Luo Zhenkun Lou |
| author_facet | Ming Gao Guijie Guo Jinzhou Huang Jake A. Kloeber Fei Zhao Min Deng Xinyi Tu Wootae Kim Qin Zhou Chao Zhang Ping Yin Kuntian Luo Zhenkun Lou |
| author_sort | Ming Gao |
| collection | DOAJ |
| description | C-terminal binding protein (CtBP) interacting protein (CtIP) is a fundamental factor for the initiation of DNA end resection to initiate DNA repair. Here the authors reveal mechanistic insights into the regulation of CtIP via the deubiquitinase USP52. |
| first_indexed | 2024-12-21T10:14:39Z |
| format | Article |
| id | doaj.art-0cbdcde06d9e49459d90c92d2584a861 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T10:14:39Z |
| publishDate | 2020-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0cbdcde06d9e49459d90c92d2584a8612022-12-21T19:07:36ZengNature PortfolioNature Communications2041-17232020-10-0111111310.1038/s41467-020-19202-0USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIPMing Gao0Guijie Guo1Jinzhou Huang2Jake A. Kloeber3Fei Zhao4Min Deng5Xinyi Tu6Wootae Kim7Qin Zhou8Chao Zhang9Ping Yin10Kuntian Luo11Zhenkun Lou12Department of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicC-terminal binding protein (CtBP) interacting protein (CtIP) is a fundamental factor for the initiation of DNA end resection to initiate DNA repair. Here the authors reveal mechanistic insights into the regulation of CtIP via the deubiquitinase USP52.https://doi.org/10.1038/s41467-020-19202-0 |
| spellingShingle | Ming Gao Guijie Guo Jinzhou Huang Jake A. Kloeber Fei Zhao Min Deng Xinyi Tu Wootae Kim Qin Zhou Chao Zhang Ping Yin Kuntian Luo Zhenkun Lou USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP Nature Communications |
| title | USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP |
| title_full | USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP |
| title_fullStr | USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP |
| title_full_unstemmed | USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP |
| title_short | USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP |
| title_sort | usp52 regulates dna end resection and chemosensitivity through removing inhibitory ubiquitination from ctip |
| url | https://doi.org/10.1038/s41467-020-19202-0 |
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