Effects of palbociclib on oral squamous cell carcinoma and the role of <i>PIK3CA</i> in conferring resistance

Effects of palbociclib on oral squamous cell carcinoma and the role of <i>PIK3CA</i> in conferring resistance

<b>Objective</b> Lack of effective therapies remains a problem in the treatment of oral squamous cell carcinoma (OSCC), especially in patients with advanced tumors. OSCC development is driven by multiple aberrancies within the cell cycle pathway, including amplification of cyclin D1 and...

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Bibliographic Details
Main Authors: Nur Syafinaz Zainal, Bernard Kok Bang Lee, Zheng Wei Wong, Iuan Sheau Chin, Pei San Yee, Chai Phei Gan, Kein Seong Mun, Zainal Ariff Abdul Rahman, J. Silvio Gutkind, Vyomesh Patel, Sok Ching Cheong
Format: Article
Language:English
Published: China Anti-Cancer Association 2019-06-01
Series:Cancer Biology & Medicine
Subjects:
OSCC
palbociclib
CDK4/6 inhibitors
<i>PIK3CA</i>
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1421

Internet

http://www.cancerbiomed.org/index.php/cocr/article/view/1421

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