Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors
A series of novel N-phenylbenzamide derivatives were synthesized and their anti-EV 71 activities were assayed in vitro. Among the compounds tested, 3-amino-N-(4-bromophenyl)-4-methoxybenzamide (1e) was active against the EV 71 strains tested at low micromolar concentrations, with IC50 values ranging...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-03-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/18/3/3630 |
| _version_ | 1811308914907545600 |
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| author | Zhuo-Rong Li Yu-Huan Li Jian-Dong Jiang Yan-Ping Li Rong-Mei Gao Wei-Ying He Lan-Hu Hao Hui-Qiang Wang Xing-Yue Ji |
| author_facet | Zhuo-Rong Li Yu-Huan Li Jian-Dong Jiang Yan-Ping Li Rong-Mei Gao Wei-Ying He Lan-Hu Hao Hui-Qiang Wang Xing-Yue Ji |
| author_sort | Zhuo-Rong Li |
| collection | DOAJ |
| description | A series of novel N-phenylbenzamide derivatives were synthesized and their anti-EV 71 activities were assayed in vitro. Among the compounds tested, 3-amino-N-(4-bromophenyl)-4-methoxybenzamide (1e) was active against the EV 71 strains tested at low micromolar concentrations, with IC50 values ranging from 5.7 ± 0.8–12 ± 1.2 μM, and its cytotoxicity to Vero cells (TC50 = 620 ± 0.0 μM) was far lower than that of pirodavir (TC50 = 31 ± 2.2 μM). Based on these results, compound 1e is a promising lead compound for the development of anti-EV 71 drugs. |
| first_indexed | 2024-04-13T09:31:51Z |
| format | Article |
| id | doaj.art-0cbf510db7ca49f5ac2da5be55c54bed |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T09:31:51Z |
| publishDate | 2013-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-0cbf510db7ca49f5ac2da5be55c54bed2022-12-22T02:52:12ZengMDPI AGMolecules1420-30492013-03-011833630364010.3390/molecules18033630Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 InhibitorsZhuo-Rong LiYu-Huan LiJian-Dong JiangYan-Ping LiRong-Mei GaoWei-Ying HeLan-Hu HaoHui-Qiang WangXing-Yue JiA series of novel N-phenylbenzamide derivatives were synthesized and their anti-EV 71 activities were assayed in vitro. Among the compounds tested, 3-amino-N-(4-bromophenyl)-4-methoxybenzamide (1e) was active against the EV 71 strains tested at low micromolar concentrations, with IC50 values ranging from 5.7 ± 0.8–12 ± 1.2 μM, and its cytotoxicity to Vero cells (TC50 = 620 ± 0.0 μM) was far lower than that of pirodavir (TC50 = 31 ± 2.2 μM). Based on these results, compound 1e is a promising lead compound for the development of anti-EV 71 drugs.http://www.mdpi.com/1420-3049/18/3/3630synthesisEV 71N-phenylbenzamide |
| spellingShingle | Zhuo-Rong Li Yu-Huan Li Jian-Dong Jiang Yan-Ping Li Rong-Mei Gao Wei-Ying He Lan-Hu Hao Hui-Qiang Wang Xing-Yue Ji Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors Molecules synthesis EV 71 N-phenylbenzamide |
| title | Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors |
| title_full | Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors |
| title_fullStr | Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors |
| title_full_unstemmed | Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors |
| title_short | Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors |
| title_sort | synthesis and antiviral activity of n phenylbenzamide derivatives a novel class of enterovirus 71 inhibitors |
| topic | synthesis EV 71 N-phenylbenzamide |
| url | http://www.mdpi.com/1420-3049/18/3/3630 |
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