WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration
Intervertebral disc degeneration (IVDD) is the leading cause of low back pain and Nucleus pulposus cell senescence contributes a lot to its progression. Here, the authors reveal WTAP-mediated m6A modification of lncRNA NORAD promotes IVDD.
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28990-6 |
| _version_ | 1818356274850430976 |
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| author | Gaocai Li Liang Ma Shujie He Rongjin Luo Bingjin Wang Weifeng Zhang Yu Song Zhiwei Liao Wencan Ke Qian Xiang Xiaobo Feng Xinghuo Wu Yukun Zhang Kun Wang Cao Yang |
| author_facet | Gaocai Li Liang Ma Shujie He Rongjin Luo Bingjin Wang Weifeng Zhang Yu Song Zhiwei Liao Wencan Ke Qian Xiang Xiaobo Feng Xinghuo Wu Yukun Zhang Kun Wang Cao Yang |
| author_sort | Gaocai Li |
| collection | DOAJ |
| description | Intervertebral disc degeneration (IVDD) is the leading cause of low back pain and Nucleus pulposus cell senescence contributes a lot to its progression. Here, the authors reveal WTAP-mediated m6A modification of lncRNA NORAD promotes IVDD. |
| first_indexed | 2024-12-13T19:54:37Z |
| format | Article |
| id | doaj.art-0cc1780d975240769fe22cbab89c59ed |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T19:54:37Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0cc1780d975240769fe22cbab89c59ed2022-12-21T23:33:20ZengNature PortfolioNature Communications2041-17232022-03-0113111510.1038/s41467-022-28990-6WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degenerationGaocai Li0Liang Ma1Shujie He2Rongjin Luo3Bingjin Wang4Weifeng Zhang5Yu Song6Zhiwei Liao7Wencan Ke8Qian Xiang9Xiaobo Feng10Xinghuo Wu11Yukun Zhang12Kun Wang13Cao Yang14Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Cardiology, Union Hospital, and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyIntervertebral disc degeneration (IVDD) is the leading cause of low back pain and Nucleus pulposus cell senescence contributes a lot to its progression. Here, the authors reveal WTAP-mediated m6A modification of lncRNA NORAD promotes IVDD.https://doi.org/10.1038/s41467-022-28990-6 |
| spellingShingle | Gaocai Li Liang Ma Shujie He Rongjin Luo Bingjin Wang Weifeng Zhang Yu Song Zhiwei Liao Wencan Ke Qian Xiang Xiaobo Feng Xinghuo Wu Yukun Zhang Kun Wang Cao Yang WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration Nature Communications |
| title | WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration |
| title_full | WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration |
| title_fullStr | WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration |
| title_full_unstemmed | WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration |
| title_short | WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration |
| title_sort | wtap mediated m6a modification of lncrna norad promotes intervertebral disc degeneration |
| url | https://doi.org/10.1038/s41467-022-28990-6 |
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