Fluoxetine protection in decompression sickness in mice is enhanced by blocking TREK-1 potassium channel with the spadin antidepressant.

Fluoxetine protection in decompression sickness in mice is enhanced by blocking TREK-1 potassium channel with the spadin antidepressant.

In mice, disseminated coagulation, inflammation and ischemia induce neurological damages that can lead to the death. These symptoms result from circulating bubbles generated by a pathogenic decompression. An acute fluoxetine treatment or the presence of the TREK-1 potassium channel increased the sur...

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Bibliographic Details
Main Authors: Nicolas eVallée, Kate eLambrechts, Sébastien eDe Maistre, Perrine eRoyal, Jean eMazella, Marc eBorsotto, Catherine eHeurteaux, Jacques eAbraini, Jean-Jacques eRisso, Jean-Eric eBlatteau
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Physiology
Subjects:
Decompression Sickness
Depression
Diving
Fluoxetine
Inflammation
Ischemia
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00042/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00042/full

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