Joint replacement risk is markedly increased in alkaptonuria (AKU) in those with prior arthroplasty

Joint replacement risk is markedly increased in alkaptonuria (AKU) in those with prior arthroplasty

Background: Increased homogentisic acid (HGA) in alkaptonuria (AKU) causes severe arthritis. Nitisinone reduces the production of HGA, but whether it also decreases arthroplasty was examined in 237 AKU patients. Patients and methods: Patients attending the United Kingdom National Alkaptonuria Centre...

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Bibliographic Details
Main Authors: L.R. Ranganath, M. Khedr, B.P. Norman, J.H. Hughes, R. Imrich, J.B. Arnoux, B. Olsson, M. Rudebeck, J.A. Gallagher, G. Bou-Gharios
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
Ochronosis
Alkaptonuria
Joint replacement
Nitisinone
Prevalence
Incidence
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426924000508

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http://www.sciencedirect.com/science/article/pii/S2214426924000508

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