Identification of a novel, MSC-induced macrophage subtype via single-cell sequencing: implications for intervertebral disc degeneration therapy

Identification of a novel, MSC-induced macrophage subtype via single-cell sequencing: implications for intervertebral disc degeneration therapy

Intervertebral disc (IVD) degeneration is a common pathological condition associated with low back pain. Recent evidence suggests that mesenchymal signaling cells (MSCs) promote IVD regeneration, but underlying mechanisms remain poorly defined. One postulated mechanism is via modulation of macrophag...

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Bibliographic Details
Main Authors: Jinsha Koroth, Casey Chitwood, Ramya Kumar, Wei-Han Lin, Benjamin T. Reves, Todd Boyce, Theresa M. Reineke, Arin M. Ellingson, Casey P. Johnson, Laura S. Stone, Kimberly C. Chaffin, Narendra K. Simha, Brenda M. Ogle, Elizabeth W. Bradley
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
STRO3
IFN gamma
single cell sequence (scRNA-seq)
back pain
Coffilin
CCL2
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1286011/full

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https://www.frontiersin.org/articles/10.3389/fcell.2023.1286011/full

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