Biological Functions of the DNA Glycosylase NEIL3 and Its Role in Disease Progression Including Cancer

The accumulation of oxidative DNA base damage can severely disrupt the integrity of the genome and is strongly associated with the development of cancer. DNA glycosylase is the critical enzyme that initiates the base excision repair (BER) pathway, recognizing and excising damaged bases. The Nei endo...

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Bibliographic Details
Main Authors: Lang Chen, Xuan Huan, Xi-Dan Gao, Wu-Han Yu, Guo-Hui Xiao, Teng-Fei Li, Zhe-Yuan Wang, You-Cheng Zhang
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/14/23/5722