A prefrontal network model operating near steady and oscillatory states links spike desynchronization and synaptic deficits in schizophrenia

A prefrontal network model operating near steady and oscillatory states links spike desynchronization and synaptic deficits in schizophrenia

Schizophrenia results in part from a failure of prefrontal networks but we lack full understanding of how disruptions at a synaptic level cause failures at the network level. This is a crucial gap in our understanding because it prevents us from discovering how genetic mutations and environmental ri...

Full description

Bibliographic Details
Main Authors: David A Crowe, Andrew Willow, Rachael K Blackman, Adele L DeNicola, Matthew V Chafee, Bagrat Amirikian
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-02-01
Series:eLife
Subjects:
spike synchrony
asynchronous network
synchronous network
excitation - inhibition balance
spiking network model
NMDAR
Online Access:https://elifesciences.org/articles/79352

Internet

https://elifesciences.org/articles/79352

Similar Items