Proviral location affects cognate peptide–induced virus production and immune recognition of HIV-1–infected T cell clones

Proviral location affects cognate peptide–induced virus production and immune recognition of HIV-1–infected T cell clones

BACKGROUND HIV-1–infected CD4+ T cells contribute to latent reservoir persistence by proliferating while avoiding immune recognition. Integration features of intact proviruses in elite controllers (ECs) and people on long-term therapy suggest that proviruses in specific chromosomal locations can eva...

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Bibliographic Details
Main Authors: Filippo Dragoni, Abena K. Kwaa, Caroline C. Traut, Rebecca T. Veenhuis, Bezawit A. Woldemeskel, Angelica Camilo-Contreras, Hayley E. Raymond, Arbor G. Dykema, Eileen P. Scully, Amanda M. Rosecrans, Kellie N. Smith, Frederic D. Bushman, Francesco R. Simonetti, Joel N. Blankson
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-11-01
Series:The Journal of Clinical Investigation
Subjects:
AIDS/HIV
Online Access:https://doi.org/10.1172/JCI171097

Internet

https://doi.org/10.1172/JCI171097

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