TRPV4‐mediated Ca2+ deregulation causes mitochondrial dysfunction via the AKT/α‐synuclein pathway in dopaminergic neurons

TRPV4‐mediated Ca2+ deregulation causes mitochondrial dysfunction via the AKT/α‐synuclein pathway in dopaminergic neurons

AbstractMutations in the gene encoding the transient receptor potential vanilloid member 4 (TRPV4), a Ca2+ permeable nonselective cation channel, cause TRPV4‐related disorders. TRPV4 is widely expressed in the brain; however, the pathogenesis underlying TRPV4‐mediated Ca2+ deregulation in neurodevel...

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Bibliographic Details
Main Authors: Xiao Sun, Jun Kong, Shuangshan Dong, Hiroki Kato, Hiroshi Sato, Yuta Hirofuji, Yosuke Ito, Lu Wang, Takahiro A. Kato, Michiko Torio, Yasunari Sakai, Shouichi Ohga, Satoshi Fukumoto, Keiji Masuda
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:FASEB BioAdvances
Subjects:
calcium
dental pulp stem cells
mitochondria
transient receptor potential vanilloid member 4
α‐synuclein
Online Access:https://doi.org/10.1096/fba.2023-00057

Internet

https://doi.org/10.1096/fba.2023-00057

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