The Neuroprotective Potential of Rho-Kinase Inhibition in Promoting Cell Survival and Reducing Reactive Gliosis in Response to Hypoxia in Isolated Bovine Retina

The Neuroprotective Potential of Rho-Kinase Inhibition in Promoting Cell Survival and Reducing Reactive Gliosis in Response to Hypoxia in Isolated Bovine Retina

Aims: To investigate the outcomes of Rho-kinase inhibition in the electrophysiological ex vivo model of the isolated perfused vertebrate retina under hypoxia. Methods: Bovine retinas were perfused with an oxygen saturated nutrient solution with or without the Rho-kinase inhibitor H-1152P. The retina...

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Bibliographic Details
Main Authors: Aizhan Alt, Ralf-Dieter Hilgers, Aysegül Tura, Khaled Nassar, Toni Schneider, Arno Hueber, Kai Januschowski, Salvatore Grisanti, Julia Lüke, Matthias Lüke
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Electroretinogram
Neuroprotection
H-1152P
Astrocyte
Müller cell
Microglia
Cathepsin-B
Online Access:http://www.karger.com/Article/FullText/350138

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http://www.karger.com/Article/FullText/350138

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