Antioxidative CXXC Peptide Motif From Mesencephalic Astrocyte-Derived Neurotrophic Factor Antagonizes Programmed Cell Death

Antioxidative CXXC Peptide Motif From Mesencephalic Astrocyte-Derived Neurotrophic Factor Antagonizes Programmed Cell Death

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a potent survival-promoting protein with neurorestorative effect for neurodegenerative diseases. Its mechanism of action, albeit poorly known, depends strongly on the CXXC motif (CKGC). Here we studied the survival-promoting properties of...

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Bibliographic Details
Main Authors: Valentina Božok, Li-ying Yu, Jaan Palgi, Urmas Arumäe
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CXXC motif
apoptosis
Fas
reactive oxygen species
MANF
dopaminergic neurons
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2018.00106/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2018.00106/full

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