RNA Binding Motif 5 (RBM5) in the CNS—Moving Beyond Cancer to Harness RNA Splicing to Mitigate the Consequences of Brain Injury

RNA Binding Motif 5 (RBM5) in the CNS—Moving Beyond Cancer to Harness RNA Splicing to Mitigate the Consequences of Brain Injury

Gene splicing modulates the potency of cell death effectors, alters neuropathological disease processes, influences neuronal recovery, but may also direct distinct mechanisms of secondary brain injury. Therapeutic targeting of RNA splicing is a promising avenue for next-generation CNS treatments. RN...

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Bibliographic Details
Main Authors: Travis C. Jackson, Patrick M. Kochanek
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
RBM5
brain
alternative splicing
neuronal death
gene expression
RNA-binding protein
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00126/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2020.00126/full

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