Practical and analytical considerations when performing interim analyses in diagnostic test accuracy studies

Practical and analytical considerations when performing interim analyses in diagnostic test accuracy studies

Abstract Interim analysis is a common methodology in randomised clinical trials but has received less attention in studies of diagnostic test accuracy. In such studies, early termination for futility may be beneficial if early evidence indicates that a diagnostic test is unlikely to achieve a clinic...

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Bibliographic Details
Main Authors: Susannah Fleming, Lazaro Mwandigha, Thomas R. Fanshawe
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Diagnostic and Prognostic Research
Subjects:
Diagnostic accuracy
Interim analysis
Adaptive design
Group sequential methods
Stopping rule
Sensitivity
Online Access:https://doi.org/10.1186/s41512-024-00174-4

Internet

https://doi.org/10.1186/s41512-024-00174-4

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