Lymphocyte infiltration and antitumoral effect promoted by cytotoxic inflammatory proteins formulated as self-assembling, protein-only nanoparticles

Lymphocyte infiltration and antitumoral effect promoted by cytotoxic inflammatory proteins formulated as self-assembling, protein-only nanoparticles

Two human proteins involved in the inflammatory cell death, namely Gasdermin D (GSDMD) and the Mixed Lineage Kinase Domain-Like (MLKL) protein have been engineered to accommodate an efficient ligand of the tumoral cell marker CXCR4, and a set of additional peptide agents that allow their spontaneous...

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Bibliographic Details
Main Authors: Carlos Martínez-Torró, Lorena Alba-Castellón, Luis Miguel Carrasco-Díaz, Naroa Serna, Laura Imedio, Alberto Gallardo, Isolda Casanova, Ugutz Unzueta, Esther Vázquez, Ramón Mangues, Antonio Villaverde
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Recombinant proteins
Biomaterials
Nanoparticles
Pyroptosis
Cancer
Drug delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223007667

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223007667

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