Aβ Chronic Exposure Promotes an Activation State of Microglia through Endocannabinoid Signalling Imbalance

Aβ Chronic Exposure Promotes an Activation State of Microglia through Endocannabinoid Signalling Imbalance

Dysfunctional phenotype of microglia, the primary brain immune cells, may aggravate Alzheimer’s disease (AD) pathogenesis by releasing proinflammatory factors, such as nitric oxide (NO). The endocannabinoids <i>N</i>-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) are bi...

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Bibliographic Details
Main Authors: Lucia Scipioni, Daniel Tortolani, Francesca Ciaramellano, Federico Fanti, Thais Gazzi, Manuel Sergi, Marc Nazaré, Sergio Oddi, Mauro Maccarrone
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
microglia
endocannabinoid system
β-amyloid peptides
Online Access:https://www.mdpi.com/1422-0067/24/7/6684

Internet

https://www.mdpi.com/1422-0067/24/7/6684

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