Single-cell transcriptomics reveals tumor microenvironment remodeling in hepatocellular carcinoma with varying tumor subclonal complexity

IntroductionThe complexity of tumor cell subclonal structure has been extensively investigated in hepatocellular carcinoma. However, the role of subclonal complexity in reshaping the tumor microenvironment (TME) remains poorly understood.MethodsWe integrated single-cell transcriptome sequencing data...

Full description

Bibliographic Details
Main Authors: Jian Shi, Yanru Zhang, Lixia Xu, Fang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-08-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2024.1467682/full