Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells.

Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells.

<h4>Rationale</h4>Age-related macular degeneration (AMD) is the most prevalent form of irreversible blindness in the developed world. Aging, inflammation and complement dysregulation affecting the retinal pigment epithelium (RPE), are considered significant contributors in its pathogenes...

Full description

Bibliographic Details
Main Authors: Nikolaos E Efstathiou, Giannis A Moustafa, Daniel E Maidana, Eleni K Konstantinou, Shoji Notomi, Paulo R T Barbisan, Constantine D Georgakopoulos, Joan W Miller, Demetrios G Vavvas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0244307

Internet

https://doi.org/10.1371/journal.pone.0244307

Similar Items